2024

Viral modulation of type II interferon increases T cell adhesion and virus spread.
Jacobsen C, Plückebaum N, Ssebyatika G, Beyer S, Mendes-Monteiro L, Wang J, Kropp KA, González-Motos V, Steinbrück L, Ritter B, Rodríguez-González C, Böning H, Nikolouli E, Kinchington PR, Lachmann N, Depledge DP, Krey T, Viejo-Borbolla A.
Nat Commun. 2024 Jun 22;15(1):5318. doi: 10.1038/s41467-024-49657-4. PMID: 38909022 Free PMC article.

Targeting cellular cathepsins inhibits hepatitis E virus entry.
Klöhn M, Burkard T, Janzen J, Haase JA, Gömer A, Fu R, Ssebyatika G, Nocke MK, Brown RJP, Krey T, Dao Thi VL, Kinast V, Brüggemann Y, Todt D, Steinmann E.
Hepatology. 2024 May 10. doi: 10.1097/HEP.0000000000000912. Online ahead of print. PMID: 38728662

SARS-CoV-2 M^pro responds to oxidation by forming disulfide and NOS/SONOS bonds.
Reinke PYA, Schubert R, Oberthür D, Galchenkova M, Rahmani Mashhour A, Günther S, Chretien A, Round A, Seychell BC, Norton-Baker B, Kim C, Schmidt C, Koua FHM, Tolstikova A, Ewert W, Peña Murillo GE,
Mills G, Kirkwood H, Brognaro H, Han H, Koliyadu J, Schulz J, Bielecki J, Lieske J, Maracke J, Knoska J, Lorenzen K, Brings L, Sikorski M, Kloos M, Vakili M, Vagovic P, Middendorf P, de Wijn R, Bean R, Letrun R, Han S, Falke S, Geng T, Sato T, Srinivasan V, Kim Y, Yefanov OM, Gelisio L, Beck T, Doré AS, Mancuso AP, Betzel C, Bajt S, Redecke L, Chapman HN, Meents A, Turk D, Hinrichs W, Lane TJ.
Nat Commun. 2024 May 7;15(1):3827. doi: 10.1038/s41467-024-48109-3. PMID: 38714735 Free PMC article.

Inhibitory effect of sorangicin A against mutant DNA-dependent RNA polymerase in the obligate intracellular bacterium Chlamydia trachomatis.
Li Q, Jansen H, Hansen G, Nurjadi D, Herrmann J, Stadler M, Brönstrup M, Müller R, He C, Graspeuntner S, Rupp J, Shima K.
Int J Antimicrob Agents. 2024 May;63(5):107132. doi: 10.1016/j.ijantimicag.2024.107132. Epub 2024 Mar 1. PMID: 38432602

A streamlined approach to structure elucidation using in cellulo crystallized recombinant proteins, InCellCryst.
Schönherr R, Boger J, Lahey-Rudolph JM, Harms M, Kaiser J, Nachtschatt S, Wobbe M, Duden R, König P, Bourenkov G, Schneider TR, Redecke L.
Nat Commun. 2024 Feb 24;15(1):1709. doi: 10.1038/s41467-024-45985-7. PMID: 38402242 Free PMC article.

Convolutional neural network approach for the automated identification of in cellulo crystals.
Kardoost A, Schönherr R, Deiter C, Redecke L, Lorenzen K, Schulz J, de Diego I.
J Appl Crystallogr. 2024 Feb 23;57(Pt 2):266-275. doi: 10.1107/S1600576724000682. eCollection 2024 Apr 1. PMID: 38596734 Free PMC article.

Late Onset of Primary Hemophagocytic Lymphohistiocytosis (HLH) with a Novel Constellation of Compound Heterozygosity Involving Two Missense Variants in the PRF1 Gene.
Stadermann A, Haar M, Riecke A, Mayer T, Neumann C, Bauer A, Schulz A, Nagarathinam K, Gebauer N, Böhm S, Groß M, Grunert M, Müller M, Witte H.
Int J Mol Sci. 2024 Feb 27;25(5):2762. doi: 10.3390/ijms25052762. PMID: 38474010 Free PMC article. Review.

Drug repurposing screen identifies lonafarnib as respiratory syncytial virus fusion protein inhibitor.
Sake SM, Zhang X, Rajak MK, Urbanek-Quaing M, Carpentier A, Gunesch AP, Grethe C, Matthaei A, Rückert J, Galloux M, Larcher T, Le Goffic R, Hontonnou F, Chatterjee AK, Johnson K, Morwood K, Rox K, Elgaher WAM, Huang J, Wetzke M, Hansen G, Fischer N, Eléouët JF, Rameix-Welti MA, Hirsch AKH, Herold E, Empting M, Lauber C, Schulz TF, Krey T, Haid S, Pietschmann T.
Nat Commun. 2024 Feb 8;15(1):1173. doi: 10.1038/s41467-024-45241-y. PMID: 38332002 Free PMC article.