2024
Epitope-focused immunogens targeting the hepatitis C virus glycoproteins induce broadly neutralizing antibodies.
Nagarathinam K, Scheck A, Labuhn M, Ströh LJ, Herold E, Veselkova B, Tune S, Cramer JT, Rosset S, Vollers SS, Bankwitz D, Ballmaier M, Böning H, Roth E, Khera T, Ahsendorf-Abidi HP, Dittrich-Breiholz O, Obleser J, Nassal M, Jäck HM, Pietschmann T, Correia BE, Krey T.
Sci Adv. 2024 Dec 6;10(49):eado2600. doi: 10.1126/sciadv.ado2600. Epub 2024 Dec 6. PMID: 39642219
A human monoclonal antibody neutralizing SARS-CoV-2 Omicron variants containing the L452R mutation.
Stein SC, Hansen G, Ssebyatika G, Ströh LJ, Ochulor O, Herold E, Schwarzloh B, Mutschall D, Zischke J, Cordes AK, Schneider T, Hinrichs I, Blasczyk R, Kleine-Weber H, Hoffmann M, Klein F, Kaiser FK, Gonzalez-Hernandez M, Armando F, Ciurkiewicz M, Beythien G, Pöhlmann S, Baumgärtner W, Osterhaus A, Schulz TF, Krey T.
J Virol. 2024 Dec 17;98(12):e0122324. doi: 10.1128/jvi.01223-24. Epub 2024 Nov 4. PMID: 39494911
Human tetraspanin CD81 facilitates invasion of Salmonella enterica into human epithelial cells.
Alvarez KG, Goral L, Suwandi A, Lasswitz L, Zapatero-Belinchón FJ, Ehrhardt K, Nagarathinam K, Künnemann K, Krey T, Wiedemann A, Gerold G, Grassl GA.
Virulence. 2024 Dec;15(1):2399792. doi: 10.1080/21505594.2024.2399792. Epub 2024 Sep 24. PMID: 39239914
Practical courses on advanced methods in macromolecular crystallization: 20 years of history and the future perspective.
Havlickova P, Gavira JA, Mesters JR, Koutska A, Kascakova B, Prudnikova T, Hilgenfeld R, Garcia-Ruiz JM, Rezacova P, Kuta Smatanova I.
J. Appl. Cryst. 2024 August 30; 57(5) 1-9. doi.org/10.1107/S1600576724007106
The NS1 protein of contemporary West African Zika virus potentiates viral replication and reduces innate immune activation.
Machmouchi D, Courageot MP, Ogire E, Redecke L, Kohl A, Desprès P, Roche M.
PLoS Negl Trop Dis. 2024 Aug 23;18(8):e0012146. doi: 10.1371/journal.pntd.0012146. eCollection 2024 Aug. PMID: 39178324
Molecular tumor board: molecularly adjusted therapy upon identification and functional validation of a novel ALK resistance mutation in a case of lung adenocarcinoma.
Arndt A, Neumann C, Riecke A, Bauer A, Müller M, Wölfle-Guter M, Grunert M, Busch H, Künstner A, von Bubnoff N, Fliedner S, Greinert D, Osius J, Nagarathinam K, Steinestel K, Gorantla SP, Gebauer N, Witte HM.
Oncologist. 2024 Jul 3:oyae143. doi: 10.1093/oncolo/oyae143. Online ahead of print. PMID: 38960389
Viral modulation of type II interferon increases T cell adhesion and virus spread.
Jacobsen C, Plückebaum N, Ssebyatika G, Beyer S, Mendes-Monteiro L, Wang J, Kropp KA, González-Motos V, Steinbrück L, Ritter B, Rodríguez-González C, Böning H, Nikolouli E, Kinchington PR, Lachmann N, Depledge DP, Krey T, Viejo-Borbolla A.
Nat Commun. 2024 Jun 22;15(1):5318. doi: 10.1038/s41467-024-49657-4. PMID: 38909022
Targeting cellular cathepsins inhibits hepatitis E virus entry.
Klöhn M, Burkard T, Janzen J, Haase JA, Gömer A, Fu R, Ssebyatika G, Nocke MK, Brown RJP, Krey T, Dao Thi VL, Kinast V, Brüggemann Y, Todt D, Steinmann E.
Hepatology. 2024 Nov 1;80(5):1239-1251. doi: 10.1097/HEP.0000000000000912. Epub 2024 May 10. PMID: 38728662
SARS-CoV-2 Mpro responds to oxidation by forming disulfide and NOS/SONOS bonds.
Reinke PYA, Schubert R, Oberthür D, Galchenkova M, Rahmani Mashhour A, Günther S, Chretien A, Round A, Seychell BC, Norton-Baker B, Kim C, Schmidt C, Koua FHM, Tolstikova A, Ewert W, Peña Murillo GE,
Mills G, Kirkwood H, Brognaro H, Han H, Koliyadu J, Schulz J, Bielecki J, Lieske J, Maracke J, Knoska J, Lorenzen K, Brings L, Sikorski M, Kloos M, Vakili M, Vagovic P, Middendorf P, de Wijn R, Bean R, Letrun R, Han S, Falke S, Geng T, Sato T, Srinivasan V, Kim Y, Yefanov OM, Gelisio L, Beck T, Doré AS, Mancuso AP, Betzel C, Bajt S, Redecke L, Chapman HN, Meents A, Turk D, Hinrichs W, Lane TJ.
Nat Commun. 2024 May 7;15(1):3827. doi: 10.1038/s41467-024-48109-3. PMID: 38714735
Inhibitory effect of sorangicin A against mutant DNA-dependent RNA polymerase in the obligate intracellular bacterium Chlamydia trachomatis.
Li Q, Jansen H, Hansen G, Nurjadi D, Herrmann J, Stadler M, Brönstrup M, Müller R, He C, Graspeuntner S, Rupp J, Shima K.
Int J Antimicrob Agents. 2024 May;63(5):107132. doi: 10.1016/j.ijantimicag.2024.107132. Epub 2024 Mar 1. PMID: 38432602
A streamlined approach to structure elucidation using in cellulo crystallized recombinant proteins, InCellCryst.
Schönherr R, Boger J, Lahey-Rudolph JM, Harms M, Kaiser J, Nachtschatt S, Wobbe M, Duden R, König P, Bourenkov G, Schneider TR, Redecke L.
Nat Commun. 2024 Feb 24;15(1):1709. doi: 10.1038/s41467-024-45985-7. PMID: 38402242
Convolutional neural network approach for the automated identification of in cellulo crystals.
Kardoost A, Schönherr R, Deiter C, Redecke L, Lorenzen K, Schulz J, de Diego I.
J Appl Crystallogr. 2024 Feb 23;57(Pt 2):266-275. doi: 10.1107/S1600576724000682. eCollection 2024 Apr 1. PMID: 38596734
Late Onset of Primary Hemophagocytic Lymphohistiocytosis (HLH) with a Novel Constellation of Compound Heterozygosity Involving Two Missense Variants in the PRF1 Gene.
Stadermann A, Haar M, Riecke A, Mayer T, Neumann C, Bauer A, Schulz A, Nagarathinam K, Gebauer N, Böhm S, Groß M, Grunert M, Müller M, Witte H.
Int J Mol Sci. 2024 Feb 27;25(5):2762. doi: 10.3390/ijms25052762. PMID: 38474010 Review.
Drug repurposing screen identifies lonafarnib as respiratory syncytial virus fusion protein inhibitor.
Sake SM, Zhang X, Rajak MK, Urbanek-Quaing M, Carpentier A, Gunesch AP, Grethe C, Matthaei A, Rückert J, Galloux M, Larcher T, Le Goffic R, Hontonnou F, Chatterjee AK, Johnson K, Morwood K, Rox K, Elgaher WAM, Huang J, Wetzke M, Hansen G, Fischer N, Eléouët JF, Rameix-Welti MA, Hirsch AKH, Herold E, Empting M, Lauber C, Schulz TF, Krey T, Haid S, Pietschmann T.
Nat Commun. 2024 Feb 8;15(1):1173. doi: 10.1038/s41467-024-45241-y. PMID: 38332002
